促甲状腺激素释放激素受体1抗体（50 ul）-Anti-Thyrotropin-Releasing Hormone Receptor 1代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Thyrotropin-releasing hormone (TRH), is a widely distributed tripeptide which acts as a hormone, a paracrine regulatory factor and a neurotransmitter/neuromodulator; it is expressed in many parts of the brain as well as in various peripheral tissues. nIn the hypothalamus, TRH is secreted from the paraventricular nucleus (VPN) by TRH neurons prior to a post-translational processing from its precursor, pro-TRH. A key player in the regulation of the hypothalamus-pituitary-thyroid (HPT) axis, TRH is released into the hypophyseal portal circulation of the median eminence and reaches the pituitary, where it binds to TRH receptors, thereby stimulates the secretion of tyrothropin (thyroid-stimulating hormone; TSH). TSH, in turn, affects the thyroid to produce T4 which is subsequently converted into its biologically-active analog, T3 - a negative mediator of TRH. In the tanycytes, ependymal cells of glial origin located in close proximity to the VPN, T4 is converted to T3 by the enzyme deiodinase II (dio2) - a counterpart to deiodinase III (dio3) which conversely inactivates the above mentioned thyroid hormones, thus so indirectly promotes the production of TRHs

免疫原: Thyrotropin-Releasing Hormone 受体 1抗体的免疫原肽段为CKQKPTEKAANYS。此免疫原序列来源于337-349 位氨基酸残基，该序列来源于大鼠Thyrotropin-releasing hormone 受体 1 (Accession编号为Q01717)。胞内, C端。

保存建议: 艾美捷为您提供的Thyrotropin-Releasing Hormone 受体 1抗体(50 ul)为室温运输，建议您收到产品后﹣20℃保存。

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