CP 339818盐酸盐（50毫克）-CP 339818 hydrochloride代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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背景资料: CP 339818 hydrochloride is a potent KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel. It appears to recognize only the inactivated conformation of KV1.3. CP 339818 hydrochloride inhibits KV1.3 expressed in brain and in T lymphocyte cells with an IC50 value of ~ 200 nM. In addition to its effect on KV1.3, CP 339818 inhibits the Shaker-related A-type K+ channel, KV1.4, expressed in brain cells with an IC50 of ~ 300 nM. CP 339818 is significantly less potent blocker of KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. CP 339818 is valuable for immune system studies, where the absence of KV1.4 makes it functionally selective for KV1.3, and it has shown suppression of T cell activation. CP 339818 hydrochloride is also valuable for the study of KV1.4 function1.

产品形式: CP 339818 hydrochloride is a potent KV1.3 channel antagonist that preferentially binds to the C-type inactivated state of the channel. It appears to recognize only the inactivated conformation of KV1.3. CP 339818 hydrochloride inhibits KV1.3 expressed in brain and in T lymphocyte cells with an IC50 value of ~ 200 nM. In addition to its effect on KV1.3, CP 339818 inhibits the Shaker-related A-type K+ channel, KV1.4, expressed in brain cells with an IC50 of ~ 300 nM. CP 339818 is significantly less potent blocker of KV1.1, KV1.2, KV1.5, KV1.6, KV3.1-4, and KV4.2. CP 339818 is valuable for immune system studies, where the absence of KV1.4 makes it functionally selective for KV1.3, and it has shown suppression of T cell activation. CP 339818 hydrochloride is also valuable for the study of KV1.4 function1.

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