卡维地洛（250毫克）-Carvedilol代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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生化试剂

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背景资料: Carvedilol is a potent nonselective β1-, β2-, and α1- adrenoceptor antagonist drug with an IC50 value of 3.8 µM. Carvedilol is also vasodilator with antioxidant, anti-inflammatory, antifibrotic and antiproliferative effects. It has “atypical” effects on β-receptors mediated by an interaction with G proteins that leads to downregulation of receptors in model systems. Experimental models demonstrate that Carvedilol blocks α1-, β1-, and β2-adrenergic receptors without exhibiting high levels of inverse agonist activity. The lack of inverse agonist activity and intrinsic sympathomimetic activity (ISA) reduces the side-effects and makes the compound better tolerated than the older β-blockers. The pharmacologic effects of carvedilol are related to the inhibition of multiple neurohormonal pathways. Additional studies indicate that some of the efficacy of carvedilol may be associated with its effects on levels of inflammatory cytokines. Carvedilol also blocks KV1. channels independently of its action on adrenoceptors5, as well as Kir2.3 channels.

产品描述: A Blocker of KV1.5 and Kir2.3 Channels and an Antagonist of Adrenoceptors

产品形式: Carvedilol is a potent nonselective β1-, β2-, and α1- adrenoceptor antagonist drug with an IC50 value of 3.8 µM. Carvedilol is also vasodilator with antioxidant, anti-inflammatory, antifibrotic and antiproliferative effects. It has “atypical” effects on β-receptors mediated by an interaction with G proteins that leads to downregulation of receptors in model systems. Experimental models demonstrate that Carvedilol blocks α1-, β1-, and β2-adrenergic receptors without exhibiting high levels of inverse agonist activity. The lack of inverse agonist activity and intrinsic sympathomimetic activity (ISA) reduces the side-effects and makes the compound better tolerated than the older β-blockers. The pharmacologic effects of carvedilol are related to the inhibition of multiple neurohormonal pathways. Additional studies indicate that some of the efficacy of carvedilol may be associated with its effects on levels of inflammatory cytokines. Carvedilol also blocks KV1. channels independently of its action on adrenoceptors5, as well as Kir2.3 channels.

保存建议: 艾美捷为您提供的Alonmone Labs原装进口的Carvedilol (250 mg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

其他: Alomone成立于1989年,已经成为全世界科学家信赖的最全面的离子通道研究工具供应商。产品覆盖离子通道、G蛋白耦联受体和神经信号研究所需的一抗、小分子、蛋白质和多肽等。所有Alomone产品均进行了生物实验验证，以冻干粉形式提供，可确保产品生物活性和保质期。Alomone可提供多种包装规格，灵活方便。作为Alomone Labs在中国的区域总代理，开云·官方站线上登录平台入口_开云(中国) 将为中国客户提供最全面的Alomone Labs产品以及客户订制化服务。