Nitrendipine is a dihydropyridine Ca2+ channel blocker. Once Nitrendipine is metabolized, it reaches the cells of the smooth muscles and cardiac muscle. It binds more effectively with L-type calcium channels in smooth muscle cells as a result of its lower resting membrane potential.
产品描述
A Potent and Selective Blocker of L-type CaV Channels
产品形式
Native voltage-gated Ca2+ channels (VGCC, CaV) are pharmacologically classified into at least five different subclasses (L-, N-, P-, Q-, and R-type), the characteristics of which are determined by the pore- forming α1 subunit. The subunits CaV1.1-1.4 (α1S, α1C, α1D and α1F) form L-type Ca2+ channels and bind dihydropyridines (DHPs) with high affinity.