N-palmitoyl-vanillamide (palvanil) is a TRPV1 agonist, a non-poignant analogue to capsaicin (capsaicinoid). It has a slower kinetic opening-onset than capsaicin, but it activates the channel more potently. It induces significantly milder side effects – e.g. imbalanced thermal homeostasis and bronchoconstriction - than capsaicin, and it seems to be suitable as a topical anti-analgesic. It is effective in reducing edema, and can inhibit inflammatory and neuropathic pain, and interestingly, in vitro data have shown that at low concentrations it encourages the proliferation of osteoclasts, and does the opposite at high concentrations.
产品描述
An Agonist of TRPV1 Channels
产品形式
Transient receptor potential vanilloid receptor 1 (TRPV1) is a non-selective cation channel that is stimulated by capsaicin, protons, endogenous lipids, and hot temperature. Upon activation, TRPV1 initiates a signaling cascade that results in elevated levels of pain-inducing factors. It is located in sensory ganglia composed of neurons that send projection throughout the periphery.