Ca2+-activated potassium channels (KCa) are a group of 6/7-TM proteins that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance, respectively). The three small-conductance Ca2+-activated K+ channels KCa2.1 (SK1), KCa2.2 (SK2), and KCa2.3 (SK3)1, and the intermediate-conductance KCa3.1 channel (IK1, SK4) play important roles in various physiological functions by modulating Ca2+-signaling cascades and regulating membrane potential, in the CNS and also peripherally.
产品描述
A Potent Activator of KCa3.1 and KCa2 Channels and a Blocker of TRPM7 Channel
产品形式
Ca2+-activated potassium channels (KCa) are a group of 6/7-TM proteins that selectively transport K+ ions across biological membranes. They are broadly classified into three subtypes: SK, IK and BK channels (small, intermediate and big conductance, respectively). The three small-conductance Ca2+-activated K+ channels KCa2.1 (SK1), KCa2.2 (SK2), and KCa2.3 (SK3)1, and the intermediate-conductance KCa3.1 channel (IK1, SK4) play important roles in various physiological functions by modulating Ca2+-signaling cascades and regulating membrane potential, in the CNS and also peripherally.