广西毒素-1E（50 ug）-Guangxitoxin-1E代理/参数/厂家-生化试剂-开云·官方站线上登录平台入口

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生化试剂

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背景资料: Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

产品形式: Guangxitoxin-1E is a 36 amino acid peptidyl toxin isolated from the Chilobrachys jingzhao (Chinese earth tiger) tarantula venom and belongs to the huwentoxin-1 family. Guangxitoxin-1E is a gating modifier of Kv2.1 (KCNB1, IC50 of 1 nM), Kv2.2 (KCNB2, IC50 of 3 nM) and Kv4.3 (KCND3, IC50 of 50 nM) channels. In pancreatic b cells, it enhances glucose-stimulated insulin secretion by broadening the cell action potential and enhancing calcium oscillations. The physiological modulation of Kv2.1 channels during glucose-induced insulin secretion is MgATP-mediated3,4. No significant effect was found on Kv1.2 (KCNA2), Kv1.3 (KCNA3), Kv1.5 (KCNA5), Kv3.2 (KCNC2), Cav1.2 (CACNA1C), Cav2.2 (CACNA1B), Nav1.5 (SCN5A), Nav1.7 (SCN9A) or Nav1.8 (SCN10A) channels.

保存建议: 艾美捷为您提供的Alonmone Labs原装进口的Guangxitoxin-1E (50 µg)产品可室温运输，建议您在收到产品后将其置于合适的温度下保存。

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