Kaliotoxin-1 is a 38 amino acid long toxin, originally isolated from the venom of Androctonus mauretanicus mauretanicus scorpion and is classified as α-KTX 3.1 scorpion toxin family, having three disulfide bridges. Kaliotoxin-1 is a potent inhibitor of large conductance Ca2+-activated K+ channels (BKCa), and it also binds and inhibits Dendrotoxin sensitive voltage-dependent K+ channels, mainly Kv1.1 (KCNA1), Kv1.2 (KCNA2) and Kv1.3 (KCNA3) with a Kd of 1.5, 25 and 0.1 nM, respectively. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of Kaliotoxin-3.
产品描述
A Powerful Blocker of KCa1.1 and certain Kv1 Channels
产品形式
Kaliotoxin-1 is a 38 amino acid long toxin, originally isolated from the venom of Androctonus mauretanicus mauretanicus scorpion and is classified as α-KTX 3.1 scorpion toxin family, having three disulfide bridges. Kaliotoxin-1 is a potent inhibitor of large conductance Ca2+-activated K+ channels (BKCa), and it also binds and inhibits Dendrotoxin sensitive voltage-dependent K+ channels, mainly Kv1.1 (KCNA1), Kv1.2 (KCNA2) and Kv1.3 (KCNA3) with a Kd of 1.5, 25 and 0.1 nM, respectively. Its binding affinity to rat brain synaptosomes is 5-fold higher than that of Kaliotoxin-3.