【KIR2DL3】小鼠抗人杀伤细胞免疫球蛋白样受体2DL3抗体-Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Long Cytoplasmic Tail 3代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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中文名称: 【KIR2DL3】小鼠抗人杀伤细胞免疫球蛋白样受体2DL3抗体

英文名字: Mouse Anti Human Killer Cell Immunoglobulin-Like Receptor， 2 Domains Long Cytoplasmic Tail 3

供应商: Prospec

产品货号: ANT-300

产品报价: ￥询价/100ug ￥20ug ￥5ug

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产品新闻

背景资料: Killer-cell immunoglobulin-like receptors （KIRs）， are a family of cell surface glycoproteins found on Natural Killer （NK） Cells， which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules， which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory， which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex （LRC）. KIR molecules are extremely polymorphic， meaning their gene sequences differ significantly between individuals， so that different individuals have different arrays/repertoires of KIR genes. The KIR proteins are categorized by the number of extracellular immunoglobulin domains （2D or 3D） and by whether they have a long （L） or short （S） cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif （ITIM）. Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DL3 is an inhibitory Killer Cell Ig-like Receptor （KIR， previously called p58 KIR， cl-6， NKAT2 or KIR-K7）， which recognizes class I MHC molecules （HLA-Cw1， -Cw3， -Cw7， and Cw8）. KIR2DL3 inhibits the activity of NK cells thus preventing cell lysis.

应用类型: ELISA and Western blot immunofluorescent staining with flow cytometric

免疫原: Anti-human KIR2DL3 mAb， is derived from hybridization of mouse P3-x63-Ag8.653 myeloma cells with spleen cells from BALB/c mice immunized with recombinant human KIR2DL3 amino acids 19-161 purified from E. coli.

来源宿主: 小鼠

反应性: 人

保存建议: 4℃大约保存1个月，为长期保存，推荐保存于-20℃。请避免反复冻融。

其他: ProSpec 是一家全球著名细胞因子蛋白生产和研发的公司，具有20多年的生产经验，专注于蛋白（重组及合成）生产研发。我们的核心产品包括：干扰素、白介素、骨蛋白、肿瘤坏死因子、成纤维生长因子、瘦素、干细胞因子、催乳素、表皮生长因子、胰岛素样生长因子、神经生长因子、集落刺激因子、激素、酶、病毒抗原以及各种重组蛋白等。n领先的生产工艺和规模使其可以提供毫克到克级蛋白，价格优于同类公司。绝大部分产品是天然成熟型蛋白，而不含有标签蛋白。考虑到大部分研究者希望能更灵活地配制蛋白溶液，ProSpec-Tany绝大部分产品没有添加保护剂或盐，这就对工艺提出了更高的要求。同时，ProSpec-Tany绝大部分产品为冻干粉，因此易于运输和保存。