MYST4 (KAT6B), EC=2.3.1.48, is a transcriptional coactivator with histone acetyltransferase activity. This protein is essential for normal mouse embryo development. Mouse mutants for MYST4 show craniofacial abnormalities, retards in post-natal development, defaults in the nervous system and neurogenique problems. Abnormal chromosomic rearengements of MYST4 with the CBP gene is involved in acute myeloid leukaemia (AML)-M4. Furthermore, in the ovary and the testis of mammals, MYST4 is mainly localized in specialized cells involved in male and female gametogenesis. Alternative names: Histone acetyltransferase MOZ2, MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4, Monocytic leukemia zinc finger protein-related factor.
应用类型
Imunohistochemistry (IHC) Immunoprecipitation (IP), Western blot (WB)
免疫原
KLH-conjugated synthetic peptide chosen from a bovine histone acetyltrasferase MYST4 A7E390
来源宿主
兔
反应性
bovine, antibody will also react with bovine MYST4 isoforms (MORF and MORF)