中文名称

NH2O®-Glu(OH)-NH-dPEG®--Glu(OH)-NH-m-dPEG®₂4.0-250 mg

英文名字

NH₂-dPEG®₄-Glu(OH)-NH-dPEG®₄-Glu(OH)-NH-m-dPEG®₂₄-250 mg

供应商

Click Chemistry Tools

产品货号

CCT-QBD-11624-250

产品报价

￥询价/250mg

产品说明书

购买方式

银行转账、电汇、支票、现金，在线支付宝及网银支付，或直接与我们电话联系。本公司所有产品仅供科研使用，不用于临床诊断。

产品新闻

背景资料

NH 2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24，产品编号QBD-11624，是Vector Laboratories独特的专利模块化、可设计的有效载荷递送试剂之一，称为Sidewinder™。Sidewinder™产品构建在离散PEG(dPEG®)主链上，用于抗体-药物缀合物(ADC)和相关构建体。有效载荷(细胞毒素，染料，小分子)装载到链的侧臂上。远端的甲氧基封端的dPEG®24间隔基保护有效载荷并改变性能。NH 2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24(产品编号QBD-11624)的游离伯胺与羧酸或其活性酯(NHS酯、TFP酯)反应以形成稳定的酰胺键。它是Sidewinder™与生物分子的连接点(例如，mAb、Fab、Fab '、靶向肽等)。胺可以用反应性基团修饰或直接缀合至载体分子。主链含有两个羧酸侧臂。在伯胺反应、官能化或保护之后，两个侧臂可以与含胺的有效载荷缀合。缀合可以是直接的，使用EDC或另一种合适的碳二亚胺，或间接的，在首先用N-羟基琥珀酰亚胺(NHS酯)或2，3，5，6-四氟苯酚(TFP酯)官能化酸基团，然后使活性酯与含胺的有效载荷反应之后。Sidewinder™产品旨在帮助创建稳定的高DAR ADC。已发表的研究表明，将疏水性有效负载靠近抗体表面并用SuperHydrophilic™ dPEG®构建体保护它，在许多功效指标上都比将有效负载置于接头远端更好。该分子还可以修饰和优化BD、细胞运输和内化、血清半衰期和免疫原性。

产品描述

NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, is one of Vector Laboratories' unique, patented class of modular, designable payload delivery reagents called Sidewinder™. Sidewinder™ products are built on a discrete PEG (dPEG®) backbone for use in antibody-drug conjugates (ADCs) and related constructs. The payload (cytotoxin, dye, small molecule) loads onto the chain's sidearm. The distal end's methoxy-terminated dPEG®24 spacer protects payloads and modifies performance.nThe free primary amine of NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24, product number QBD-11624, reacts with carboxylic acids or their active esters (NHS ester, TFP ester) to form stable amide bonds. It is the attachment point for the Sidewinder™ to the biomolecule (e.g., mAb, Fab, Fab', targeting peptide, and so forth). The amine can be modified with a reactive group or conjugated directly to the carrier molecule. The backbone contains two carboxylic acid sidearms. After the primary amine is reacted, functionalized, or protected, the two sidearms can be conjugated to amine-containing payloads. The conjugation can be direct, using EDC or another suitable carbodiimide, or indirect, after first functionalizing the acid groups with N-hydroxysuccinimide (NHS ester) or 2,3,5,6-tetrafluorophenol (TFP ester) and then reacting the active esters with the amine-containing payloads.nSidewinder™ products are designed to facilitate the creation of stable, high-DAR ADCs. Published research has shown that putting a hydrophobic payload close to the antibody surface and protecting it with a SuperHydrophilic™ dPEG® construct is better by many measures of efficacy than putting the payload at the distal end of the linker. This molecule can also modify and optimize BD, cell trafficking and internalization, serum half-life, and immunogenicity.nThe dPEG® linkers and spacers in the Sidewinder™ construct are uniform, single molecular-weight PEGs with discrete chain lengths. In contrast, traditional, non-uniform polymer PEG linkers and spacers have a dispersed range of PEG chain lengths, each with a unique molecular weight. Unlike dispersed polymer PEGs, dPEG® products are high-purity compounds with reproducible purity profiles.nSidewinder™ molecules are also fully designable. NH2-dPEG®4-Glu(OH)-NH-dPEG®4-Glu(OH)-m-dPEG®24 can be modified to change the spacer lengths, add more sidearm attachment points, add different sidearm attachment points to carry payloads with other reactivities, change the amine attachment group to another reactive group, and many more customizations. Please inquire about your specific needs.

产品形式

白色至类白色固体

保存建议

其他

Click Chemistry Tools（CCT）公司位于美国亚利桑那州斯科茨代尔（Scottsdale,AZ）。自公司成立以来，一致致力于不断开发和扩展一系列连接产品。他们利用特别新的研究成果研发生产出新颖的交联和标记试剂。产品被广泛用于药物研发、癌症治疗以及各类诊断技术等。此外，CCT还可以提供个性化的定制产品，已满足不同用户的需求。目前CCT的产品线主要包括：Azides（Biotin-Azides）试剂、Bis-sulfone交联试剂、DBCO试剂、TCO试剂、Terminal Alkyne试剂、Tetrazine试剂、标记试剂盒以及分选用底物等。nFluoroprobes公司位于美国亚利桑那州斯科茨代尔(Scottsdale, AZ)，自成立以来，一直致力于不断开发一系列的连接(linker)产品。利用特别新的研究成果研发生产出各类新颖的交联和标记试剂。其产品被广泛用于药物研发与筛选、疾病治疗方法和诊断技术等领域。此外，Fluoroprobes还可以根据客户的个性化需求提供各类定制连接产品。代表产品有Classic Fluorescent Dyes, AZDye, Cyanine Dyes, IR Dyes, MB dyes以及一些标记试剂盒等。nQuanta Biodesign公司位于美国中部的俄亥俄州，成立于1997年。也是专注于生产研发各类标记产品的品牌之一。其研发的产品与dPEG技术相结合，生产出他们独有的专利产品dPEG Building Blocks and Linkers，被广泛用于细胞治疗和分子诊断等研究领域。另外，还可为广大科研工作者提供多种化学修饰试剂以及传统Liner等。n目前上述三个品牌都已被被Vectorlabs收购并整合到Vectorlabs产品中

注意

该页面的中文产品信息的翻译，仅供参考。准确的产品信息请以厂家的英文说明书为准。下单前，请浏览说明书确认。

分享到：