1、快速方便的操作,整个实验(从上样准备好使用羟甲基化DNA开始)不超过3个小时,其中手工操作时间不超过20分钟;2、微孔板形式让实验更灵活:适用于手工操作或者高通量分析;3、高富集效率阳性对照/阴性对照> 1000,每次反应最低上样量为0.1ug,高度重复性.兼容于下游实验分析,包括:hMeDIP-PCR and hMeDIP-chip.
已发表的部分文献: 标题:The control region of mitochondrial DNA shows an unusual CpG and non-CpG methylation pattern.作者:Bellizzi D, D'Aquila P, Scafone T, Giordano M, Riso V, Riccio A, Passarino G;杂志名称:DNA Res 标题:Induction of Tet3-dependent Epigenetic Remodeling by Low-dose Hy.作者:Tampe B, Tampe D, Zeisberg E, Müller G, Bechtel-Walz W, Koziolek M, Kalluri R, Zeisberg M;杂志名称:EBioMedicine 标题:Epigenetic balance of aberrant Rasal1 promoter methylation and hydroxymethylation regulates cardiac fibrosis.作者:Xu X, Tan X, Tampe B, Nyamsuren G, Liu X, Maier LS, Sossalla S, Kalluri R, Zeisberg M, Hasenfuss G, Zeisberg EM;杂志名称:Cardiovasc Res 标题:TREM2 upregulation correlates with 5-hydroxymethycytosine enrichment in Alzheimer's disease hippocampus.作者:Celarain N, Sánchez-Ruiz de Gordoa J, Zelaya MV, Roldán M, Larumbe R, Pulido L, Echavarri C, Mendioroz M;杂志名称:Clin Epigenetics 标题:Dynamic DNA methylation of matrix metalloproteinase-9 in the development of diabetic retinopathy.作者:Kowluru RA, Shan Y, Mishra M;杂志名称:Lab Invest 标题:Role of oxidative stress and DNA hydroxymethylation in the neurotoxicity of fine particulate matter.作者:Wei H, Feng Y, Liang F, Cheng W, Wu X, Zhou R, Wang Y;杂志名称:Toxicology 标题:Selective inhibition of CTCF binding by iAs directs TET-mediated reprogramming of 5-hydroxymethylation patterns in iAs-transformed cells.作者:Rea M, Gripshover T, Fondufe-Mittendorf Y;杂志名称:Toxicol Appl Pharmacol 标题:Crosstalk Between Histone and DNA Methylation in Regulation of Retinal Matrix Metalloproteinase-9 in Diabetes.作者:Duraisamy AJ, Mishra M, Kowluru RA;杂志名称:Invest Ophthalmol Vis Sci Epigentek 公司是全球领先的表观遗传学相关研究的技术创新者和产品开发供应商。开发了超过700多个专利产品,为表观遗传学方面的研究和新药研发提供全面系统的解决方案,涵盖样品制备、DNA/RNA甲基化(5-mc, 5-hmc, 5-fc, m6A)/DNMT分析、ChIP、组蛋白甲基化/乙酰化/去乙酰化/磷酸化/SUMO-等领域,提供小分子抑制剂、蛋白质、抗体、以及分析试剂盒产品。