Human CellExp™ Acid Sphingomyelinase, Human Recombinant
供应商
Biovision
产品货号
P1443-50
产品报价
¥已停产
产品说明书
购买方式
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产品新闻
背景资料
Sphingomyelin phosphodiesterase, which is encoded by the SMPD1 gene, is also known as acid sphingomyelinase or aSMase. There are two types of sphingomyelinases: ASM (acid), and NSM (neutral). ASM / aSMase can catalyze the hydrolysis of sphingomyelin to ceramide and phosphorylcholine with cofactor Zn2+. Ceramide, a bioactive lipid, has emerged as an important signaling molecule involved in a variety of cellular processes such as cell differentiation, apoptosis, and proliferation. Mutations in the SMPD1 gene cause Niemann–Pick disease types A and B due to deficiency in hydrolyzing sphingomyelin to ceramide. Activation of ASM can be achieved by the removal of its C terminal cysteine residue or C-terminal truncation. BioVision’s recombinant human ASM was expressed from HEK293 cells without the last three C terminal residues, and is therefore constitutively active.
序列
提供的Human CellExp™酸性鞘磷脂酶,人类重组Human CellExp™ Acid Sphingomyelinase, Human Recombinant是Biovision品牌中国区域总代理艾美捷科技产品,具体的蛋白序列可查看提供的英文版本产品说明书。
来源宿主
提供的Human CellExp™酸性鞘磷脂酶,人类重组Human CellExp™ Acid Sphingomyelinase, Human Recombinant产品来源宿主,查看该产品说明书,或者在线咨询我们。
溶解建议
Centrifuge the vial prior to opening. Reconstitute in distilled water. Do not vortex.