Functions of the cell cortex, including motility,nadhesion, and cytokinesis, are mediated by the reorganization ofnthe actin cytoskeleton and recent evidence suggests a role for thenFormin homology (FH) proteins in these processes. The proteinnencoded by this gene contains FH domains and belongs to a novel FHnprotein subfamily implicated in cell polarity. Wnt/Fz signalingnactivates the small GTPase Rho, a key regulator of cytoskeletonnarchitecture, to control cell polarity and movement duringndevelopment. Activation requires Dvl-Rho complex formation, annassembly mediated by this gene product, which is thought tonfunction as a scaffolding protein. Evidence of alternative splicingnhas been observed for this gene but the full-length nature of thesenvariants has not been determined.
应用类型
WB, IHC-P, Flow
免疫原
This DAAM1-T361 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 341-370 amino acids from the N-terminal region of human DAAM1-T361.
来源宿主
兔
反应性
人, 仓鼠
保存建议
Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.