KIR2DS3 抗体-KIR2DS3 Antibody代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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一抗

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背景资料: Killer cell immunoglobulin-like receptors (KIRs) arentransmembrane glycoproteins expressed by natural killer cells andnsubsets of T cells. The KIR genes are polymorphic and highlynhomologous and they are found in a cluster on chromosome 19q13.4nwithin the 1 Mb leukocyte receptor complex (LRC). The gene contentnof the KIR gene cluster varies among haplotypes, although severaln'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1,nKIR3DL4, KIR3DL2). The KIR proteins are classified by the number ofnextracellular immunoglobulin domains (2D or 3D) and by whether theynhave a long (L) or short (S) cytoplasmic domain. KIR proteins withnthe long cytoplasmic domain transduce inhibitory signals uponnligand binding via an immune tyrosine-based inhibitory motifn(ITIM), while KIR proteins with the short cytoplasmic domain lacknthe ITIM motif and instead associate with the TYRO protein tyrosinenkinase binding protein to transduce activating signals. The ligandsnfor several KIR proteins are subsets of HLA class I molecules;nthus, KIR proteins are thought to play an important role innregulation of the immune response.

免疫原: This KIR2DS3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3.

保存建议: Store at 4˚C for three months and -20˚C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

其他: ProSci Incorporated于1998年成立于美国加州圣地亚哥市,从事抗体等科研试剂的研发、生产和销售。产品涵盖了细胞凋亡、信号转导、免疫、肿瘤、细胞生物、神经生物、传染病等领域。ProSci拥有超过30000种单克隆抗体和多克隆抗体。ProSci的抗体大都经免疫亲和层析纯化,具有高纯度、高亲和力、特异性强等特点,所有的ProSci抗体都经过了严格的验证测试和质量控制,已保证高质量的产品。此外,ProSci还提供标记二抗,重组蛋白,细胞和组织裂解液,细胞涂片,组织切片,多肽等产品与抗体配套使用。