Vinculin is a cytoskeletal protein that plays an important role in the regulation of focal adhesions and embryonic development (1). Three structural vinculin domains include an amino-terminal head, a short flexible proline-rich region and a carboxy-terminal tail (2). Expression of vinculin were shown to be affected by the level of actin expression (2,3). Vinculin deficiencies are associated with a decrease in cell adhesion and an increase in cell motility, suggesting a possible role in metastatic growth (4). Defects in VCL are the cause of cardiomyopathy dilated type 1W (CMD1W) (5).
应用类型
E, WB
免疫原
Vinculin antibody was raised against a 23 amino acid peptide near the amino terminus of human Vinculin.
来源宿主
小鼠
反应性
人, 小鼠, 大鼠, 兔, 鸡
保存建议
Vinculin antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.