SUBUNIT: Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration.
SIMILARITY: Belongs to the ahpC/TSA family.
SUBCELLULAR LOCATION: Cytoplasm.
MISCELLANEOUS: The active site is the redox-active Cys-50 oxidized to Cys-SOH. Cys-SOH rapidly reacts with Cys-171-SH of the other subunit to form an intermolecular disulfide with a concomitant homodimer formation. The enzyme may be subsequently regenerated by reduction of the disulfide by thioredoxin.
应用类型
WB
免疫原
60-190
来源宿主
鸡
反应性
人, 小鼠, 大鼠
保存建议
PRDX2 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.