FUNCTION: Integrin α-6/β-4 is a receptor for laminin. It plays a critical structural role in the hemidesmosome of epithelial cells.
DISEASE: Defects in ITGB4 are a cause of generalized atrophic benign epidermolysis bullosa (GABEB) [MIM:226650]. This nonlethal form of junctional epidermolysis bullosa is characterized by life-long blistering of the skin, associated with hair and tooth abnormalities.
应用类型
WB
免疫原
1441-1520
来源宿主
鸡
反应性
人
保存建议
ITGB4 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.