rTS is a gene with convergent and overlapping transcription relative to thymidylate synthase (TS). rTSβ differs from rTSα by the insertion of an extra 116 nucleotides after base 128 of rTSα and an altered 3'-noncoding region such that rTSβ RNA is not complementary to TS mRNA. rTSα and rTSβ RNAs have open reading frames predicted to encode proteins of 361 and 416 amino acids, respectively. Antibody to rTSβ protein detects two proteins of the predicted molecular weight in the H630 colon tumor cell line. rTSβ is overexpressed 40-70-fold in a 5-fluorouracil-resistant H630 subline compared with 7-8-fold for TS and rTSα
应用类型
WB
免疫原
101-250
来源宿主
鸡
反应性
人
保存建议
rTS antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.