FUNCTION: Acts at E2F-responsive promoters to integrate signals provided by PHD- and/or bromodomain-containing transcription factors. Stimulates E2F-1/DP-1 transcriptional activity. Renders the activity of cyclin D1/CDK4 resistant to the inhibitory effects of p16(INK4a).
SUBUNIT: Interacts with the PHD-bromodomain of TIF1, TRIM28/TIF1B and p300/CBP. Binds to DP1. Also interacts with CDK4.
SIMILARITY: Contains 1 SERTA domain.
应用类型
WB
免疫原
1-236
来源宿主
鸡
反应性
人
保存建议
SEI1 antibody can be stored at 4˚C for short term (weeks). Long term storage should be at -20˚C. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.