整合素 B3抗体-Integrin beta 3 Antibody: APC/Cy7代理/参数/厂家-一抗-开云·官方站线上登录平台入口

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背景资料: Integrin B-3 (B3) or CD61 is a protein that in humans is encoded by the ITGB3 gene. CD61 is a cluster of differentiation found on thrombocytes. It associates with the integrin A_v chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin A_IIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of A_v/B_3 integrin or vitronectin receptor to CD31 (PECAM-1). The 2C9.G2 antibody reacts with mouse and rat CD61, and is able to block ligand binding.

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